Poisons, Their Effects and Detection: A Manual for the Use of Analytical Chemists and ExpertsBlyth, Alexander Wynter
Science
Poisons, Their Effects and Detection: A Manual for the Use of Analytical Chemists and Experts
Blyth, Alexander Wynter
Poisons
A solution of nitrate of potash, when treated with a zinc couple
(see “Foods,” p. 566), is decomposed, the nitrate being first
reduced to nitrite, as shown by its striking a red colour with
metaphenylene-diamine, and then the nitrite farther decomposing, and
ammonia appearing in the liquid. If the solution is alkalised, and
treated with aluminium foil, hydrogen is evolved, and the same
effect produced. As with all nitrates, potassic nitrate, on being
heated in a test-tube with a little water, some copper filings, and
sulphuric acid, evolves red fumes of nitric peroxide.
§ 123. =Statistics.=--Potassic nitrate, under the popular name of
“_nitre_,” is a very common domestic remedy, and is also largely
used as a medicine for cattle. There appear to be twenty cases of
potassic nitrate poisoning on record--of these, eight were caused by
the salts having been accidentally mistaken for magnesic sulphate,
sodic sulphate, or other purgative salt; two cases were due to a
similar mistake for common salt. In one instance, the nitrate was
used in strong solution as an enema, but most of the cases were due
to the taking of too large an internal dose.
§ 124. =Uses in the Arts=, &c.--Both sodic and potassic nitrates are
called “nitre” by the public indiscriminately. Sodic nitrate is
imported in large quantities from the rainless districts of Peru as
a manure. Potassic nitrate is much used in the manufacture of
gunpowder, in the preservation of animal substances, in the
manufacture of gun cotton, of sulphuric and nitric acids, &c. The
maximum medicinal dose of potassium nitrate is usually stated to be
30 grains (1·9 grm.).
§ 125. =Action of Nitrates of Sodium and Potassium.=--Both of these
salts are poisonous. Potassic nitrate has been taken with fatal
result by man; the poisonous nature of sodic nitrate is established
by experiments on animals. The action of the nitrates of the
alkalies is separated from that of the other neutral salts of
potassium, &c., because in this case the toxic action of the
combined nitric acid plays no insignificant part. Large doses, 3-5
grms. (46·3-77·2 grains), of potassic nitrate cause considerable
uneasiness in the stomach and bowels; the digestion is disturbed;
there may be vomiting and diarrhœa, and there is generally present a
desire to urinate frequently. Still larger doses, 15-30 grms.
(231·5-463 grains), rapidly produce all the symptoms of acute
gastro-enteritis--great pain, frequent vomiting (the ejected matters
being often bloody), with irregularity and slowing of the pulse;
weakness, cold sweats, painful cramps in single muscles (especially
in the calves of the legs); and, later, convulsions, aphonia, quick
collapse, and death.
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