Poisons, Their Effects and Detection: A Manual for the Use of Analytical Chemists and ExpertsBlyth, Alexander Wynter
Science
Poisons, Their Effects and Detection: A Manual for the Use of Analytical Chemists and Experts
Blyth, Alexander Wynter
Poisons
In the case of a pregnant woman, a handful of “nitre” taken in
mistake for Glauber’s salts produced abortion after half-an-hour.
The woman recovered. Sodic nitrate subcutaneously applied to frogs
kills them, in doses of ·026 grm. (·4 grain), in about two hours;
there are fibrillar twitchings of single groups of muscles and
narcosis. The heart dies last, but after ceasing to beat may, by a
stimulus, be made again to contract. Rabbits, poisoned similarly by
sodic nitrate, exhibit also narcotic symptoms; they lose
consciousness, lie upon their side, and respond only to the sharpest
stimuli. The breathing, as well as the heart, is “slowed,” and death
follows after a few spasmodic inspirations.
=Sodic nitrite= was found by Barth to be a more powerful poison,
less than 6 mgrms. (·1 grain) being sufficient to kill a rabbit of
455·5 grms. (7028 grains) weight, when subcutaneously injected. The
symptoms were very similar to those produced by the nitrate.
§ 126. The _post-mortem_ appearances from potassic nitrate are as
follows:--An inflamed condition of the stomach, with the mucous
membrane dark in colour, and readily tearing; the contents of the
stomach are often mixed with blood. In a case related by Orfila,
there was even a small perforation by a large dose of potassic
nitrate, and a remarkable preservation of the body was noted.
It is believed that the action of the nitrates is to be partly
explained by a reduction to nitrites, circulating in the blood as
such. To detect nitrites in the blood, the best method is to place
the blood in a dialyser, the outer liquid being alcohol. The
alcoholic solution may be evaporated to dryness, extracted with
water, and then tested by metaphenylene-diamine.
§ 127. =Potassic Chlorate= (KClO₃).--Potassic chlorate is in the
form of colourless, tabular crystals with four or six sides. About 6
parts of the salt are dissolved by 100 of water at 15°, the
solubility increasing with the temperature, so that at 100° nearly
60 parts dissolve; if strong sulphuric acid be dropped on the
crystals, peroxide of chlorine is evolved; when rubbed with sulphur
in a mortar, potassic chlorate detonates. When the salt is heated
strongly, it first melts, and then decomposes, yielding oxygen gas,
and is transformed into the perchlorate. If the heat is continued,
this also is decomposed, and the final result is potassic chloride.
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