As to digestion, the most excellent observations were made on men afflicted with a fistula in the abdomen, that is, a wound penetrating to the stomach. By means of this wound, it was ascertained very minutely how long it took to digest food, and what kind of transformation it underwent. From this and other experiments it appeared, that the time for digestion, though varying greatly with the various articles of food, lasts from one and one-half to five and one-half hours. Those most quickly digested are: soft sweet apples, beaten eggs, and cooked brain. To digest boiled milk, raw eggs, soft sour apples, roasted beef, liver, two hours were required. Cooked spinal marrow, raw cabbage, fresh milk, roasted beef, oysters, soft-boiled eggs, and raw ham, took nearly three hours. Wheat bread, old cheese, potatoes were digested in nearly three and one-half hours; pork, boiled cabbage, lamb's fat, not before five hours. The experiments about the effects produced by hunger were tried only on animals. The results were that during the state of starvation three-fourths of the blood disappeared; the fat was almost entirely consumed; the flesh disappeared one-half; even the skin diminished one-third, and the bones lost about one-sixth of their weight. The least decrease was found to be in the nerves, a striking proof that nerves possess a great power of self-preservation, provided there be but a minimum of matter to feed them. From numerous experiments the conclusion was drawn, that an adult weighing about one hundred and thirty pounds must die if he were to lose, say fifty pounds, by starvation. With regard to the effects of the various articles of food, experiments applied to dogs have shown that they can live on bones for a long time; but that they die if fed on sugar only, and when examined after death, no trace of any fat is to be found. Animals fed on substances that contained no phosphorus and lime became fat; but they died for want of the proper nourishment for their bones. Animals died also when nourished only with pure albumen or pure caseine. The most remarkable fact in this connection is, that they perished in the same length of time in which they would have died, _if they had taken no food whatever_. Experiments tried on man have shown that it is injurious to eat _uniform_ food. A constant change in our food is extremely nourishing and healthy. This is an experience made in prisons and barracks; changes of food are made there every day during the week, so that each day they have a different dinner. Once, a physician in England wished to try the effects of uniform food on himself. He took nothing but bread and water for forty-five days; in consequence of this he decreased eight pounds. Then he ate for four weeks but bread and sugar, then bread and oil three weeks; but finally he succumbed under his experiments, and died, after having experimented thus for eight months.