The affliction Dr. Garnett experienced on the death of his wife, was never recovered. On all occasions of anxiety which were multiplied upon him, by reason of his exquisite sensibility, he longed for the consolation her society used to afford him; and although his susceptibility to the action of external causes, would not allow him to remain in continued and unalterable gloom and melancholy, yet in solitude, and on the slightest accident, his distress returned, and he despaired of the possibility of ever retrieving his lost happiness. Had it not been for his philosophical pursuits, and the duties of his extensive practice, which kept him almost constantly engaged, it may be doubted, whether he could at this time have sustained the load of sorrow with which he was oppressed. The circumstances which remain to be mentioned are few. From the death of his wife, Dr. Garnett may be considered as unfortunate; for although a fair prospect opened before him, a series of occurrences took place, which neither his state of mind, nor his constitutional firmness enabled him to support. At the time of the formation of the Royal Institution of Great Britain, in London, Count Rumford wrote to Dr. Garnett, to whom he was then an entire stranger, inquiring into the nature and economy of Anderson's Institution, Glasgow; the plan of the lectures given, &c. &c.; and after hinting at the opportunities of acquiring reputation in London, he finally proposed that Dr. Garnett should become lecturer of the new Institution. With this proposal, arduous as was the task, to deliver a course of lectures on almost every branch of human attainment, Dr. Garnett complied, relying on his acquirements, and the tried excellence of his nature; and conscious that no difficulty could resist the indefatigable exertions which on other occasions he had so successfully applied. Flattered by the honour and respect he conceived to be paid to his abilities and qualifications; pleased with the prospect of more rapidly accumulating an independence for himself and his children; and animated with the hope of meeting with more frequent opportunities of gratifying his thirst after knowledge, his spirits were again roused, and he looked forward to new objects of interest in the advancement of his favourite pursuits. In the enthusiasm of the moment, he was known to say, that he considered his connexion with the Royal Institution, from which the country had a right to expect so much, as one of the most fortunate occurrences of his life. On the 15th October 1799, he informed a special meeting of the Managers of Anderson's Institution, of his appointment to the Professorship of Philosophy, Chemistry, and Mechanics, in the Royal Institution of Great Britain, and on that account requested permission to resign his situation. The resignation of a man, whom all loved and revered, was reluctantly, though, as tending to his personal advancement, and the promotion of science,