It is perfectly natural that the principle of excluded perpetual motion should have been first developed in the simple domain of pure mechanics. Towards the transference of that principle into the domain of general physics the idea contributed much that all physical phenomena are mechanical phenomena. But the foregoing discussion shows how little essential this notion is. The issue really involved is the recognition of a general interconnexion of nature. This once established, we see with Carnot that it is indifferent whether the mechanical laws are broken directly or circuitously. The principle of the excluded perpetual motion is very closely related to the modern principle of energy, but it is not identical with it, for the latter is to be deduced from the former only by means of a definite _formal conception_. As may be seen from the preceding exposition, the perpetual motion can be excluded without our employing or possessing the notion of _work_. The modern principle of energy results primarily from a _substantial_ conception of work and of every change of physical condition which by being reversed produces work. The strong need of such a conception, which is by no means necessary, but in a formal sense is very convenient and lucid, is exhibited in the case of J. R. Mayer and Joule. It was before remarked that this conception was suggested to both inquirers by the observation that both the production of heat and the production of mechanical work were connected with an expenditure of substance. Mayer says: "Ex nihilo nil fit," and in another place, "The creation or destruction of a force (work) lies without the province of human activity." In Joule we find this passage: "It is manifestly _absurd_ to suppose that the powers with which God has endowed matter can be destroyed." Some writers have observed in such statements the attempt at a _metaphysical_ establishment of the doctrine of energy. But we see in them simply the formal need of a simple, clear, and living grasp of the facts, which receives its development in practical and technical life, and which we carry over, as best we can, into the province of science. As a fact, Mayer writes to Griesinger: "If, finally, you ask me how I became involved in the whole affair, my answer is simply this: Engaged during a sea voyage almost exclusively with the study of physiology, I discovered the new theory for the sufficient reason that I _vividly felt the need of it_."