Although the lithic acid deposition is the most frequent, still, as the disease advances, there is a strong tendency to the formation of the alkaline; and as the remedies for the former are apt to accelerate the latter disorder, it is most important that the urine should undergo frequent examination to regulate the treatment. To recapitulate the substance of this article, it may be stated, that gravel is a disease, not dangerous in itself, but that it is always the forerunner, although not always productive, of stone; stone being formed by the collection and chymical union of the sand itself. This collection takes place in the kidney, the ureters (the vessels that convey the urine to the bladder), the bladder, and sometimes in the urethra. The stone so formed varies in its composition and size, and is one of the saddest ills that can befall human nature. Hence the importance of watching, and attending to every urinary disturbance, of which gravel forms a prominent feature, the treatment of which has been already stated; but which, as it involves more practised judgment than a non-professional invalid can be supposed to possess, had better be intrusted only to professional hands. THE END. FORMULÆ Form 1. Four to six drachms of castor oil, the ordinary black draught, a dose of salts, or a dose of Weir’s Compound Pills. Form 2. The following mixtures lessens the acrimony in making water, abdues the irritability, and tends to diminish the discharge:— Take of— Carbonate of potass 1 drachm. Nitrate of ditto 1 drachm. Mucilage of acacia 5½ oz. Hydrocyanic acid 10 drops. Syrup of Tolu 2 drachms. Mix. Take a tablespoonful in a wineglassful of water twice daily. Form 3. Take of— Linseed tea ½ pint. Spirits of Sweet Nitre 2 drachms. Battley’s Sedative 60 drops. Mix. Take three tablespoonfuls, twice or thrice daily. Form 4. Where it is inconvenient for a patient to carry a bottle about his person, the following electuary, combining the essential ingredients of the former two, may be substituted:— Take of— Lenitive electuary 2 oz. Conserve of roses 2 oz. Strong mucilage of acacia 2 oz. Nitrate of potass 2 drachms. Mix. Dose—Two teaspoonfuls twice or thrice a day. Form 5. A good combination, that may be taken even in the inflammatory stage. Take of— Cubebs 2 oz. Carbonate of magnesia 1 drachm. Mix. Dose—A dessert- or tablespoonful twice or thrice daily. SPECIFIC REMEDIES.