hardened and cut on a brain-microtome. The anterior and posterior segments are sectioned vertically transversely, the central segment is cut horizontally. By this method cortical lesions may be accurately located, and the entire course of degenerating fibres followed out. _Method of Meynert._ This method aims to separate all portions of the brain possessing differences of internal structure that may be taken as indicating difference in significance, and to compare them by weight. The natural furrows or fissures are used as incision-lines, and three series of dissections are made, the first of which, here given, is the separation of the brain into three parts, the brain-mantle, brain-stem and cerebellum. The brain, with pia still intact, is placed base upward, with cerebellum toward operator. The arachnoid covering the fissure of Sylvius is cut or torn, and the island exposed. The three furrows bounding it must be plainly seen. The pia between the optic tract and uncus, as well as that in the middle portion of the transverse fissure between corpora quadrigemina and corpus callosum, is cut, and the under surface of the splenium of the corpus callosum is freed from membranous adhesions to the corpora quadrigemina and the pineal body. When the medulla with pons and cerebellum is now elevated the transverse fissure gapes open, and permits a free look into the lateral ventricles. The brain-mantle on both sides is now separated from the brain-stem at the basal portion of its frontal end. The knife, held nearly horizontal, is introduced into the fissure between the posterior border of the orbital convolutions and the anterior border of the lamina perforata anterior; and a cut is made slightly downward, not quite parallel with the orbital surface, about 3 cm. anteriorly in the medulla of the orbital convolutions, around the under surface of the head of the corpus striatum. The temporal ends of the brain-mantle are then cut through, the knife moving externally between the temporal lobe and the island, inside between the descending horn of the lateral ventricle and the optic tract. As soon as the inner cut has been extended beyond the outer corpus geniculatum on both sides, the knife is turned downward at right angles, in a curving stroke, to cut through the junction of the occipital lobes with the stem, internally along the portion of the corpus striatum adjacent to the optic thalamus, externally between the junction of the first temporal convolution with the operculum on one side, and the posterior end of the island on the other. When this has been done on both sides the blade of the knife is turned forward in a semicircular stroke. The posterior end of the brain-stem is gradually lifted up out of the mantle by elevating the cerebellum and medulla oblongata. The upper peduncle of the arch of the brain-mantle along the upper border of the island and