The vagotonic nerves contract the pupil, make saliva and gastric juice flow, slow down the heart beats, decrease the blood pressure, promote sexual activities, etc. The sympathetic nerves on the contrary, dilate the pupil, dry the mouth, stop the gastric activities, increase the heart beats, raise the blood pressure, decrease or arrest the sexual activities, etc. In peaceful sleep, we observe that the vagotonic functions hold full sway. In sleep, our pupils are contracted. Even when they have been dilated by atropine, they become contracted again in sleep. In sleep, the digestive organs continue to perform their specific work, all the popular beliefs to the contrary notwithstanding. Infants and animals generally go to sleep as soon as they finish feeding. Animals digest infinitely better if allowed to sleep after being fed, than if compelled to stay awake, walk or run. The activity of the sexual organs is as great in sleep as in waking life; in certain cases, it is even greater. At certain times, during sleep, the pressure of the blood in the brain is greatly reduced, and certain authors have concluded that sleep was characterized by brain anaemia, which some of them consider as the cause of sleep. Indeed, unconsciousness can be induced by producing a temporary brain anaemia, for instance by compressing the carotid arteries of the neck for a minute or so. Sleepiness almost always appears then and lasts as long as the pressure is exerted. Special manometers show that the fall in the blood pressure invariably precedes the appearance of sleep. In dogs whose skulls have been trephined for purposes of observation, the brain can be seen to turn pale as soon as the animals fall asleep. But we have here simply one of the vagotonic activities mentioned previously. In the normal organism, the blood pressure should be low, rising only in emergencies, when the organism is facing some danger and must be prepared for fight or flight. And in fact, the slightest light, noise, pain or smell stimulus, is sufficient to bring the blood back to the brain during sleep. Our sympathetic nerves are on the watch and even if the subject does not wake up, they rush the blood whenever it is needed for emergency action, in this case, to the general switchboard of the organism, the brain. But this so-called brain anaemia is not constant during the entire period of sleep. The pressure falls gradually before sleep sets in and only reaches its minimum an hour after sleep has begun. Then it increases gradually and becomes normal again about the usual waking time. We shall see later that attention follows an identical curve. It has been pointed out that in sleep the respiration becomes slower and that the amount of air inspired and consequently of oxygen assimilated is lowered. But inaction in the waking states will show exactly the same results.