The psychophysical system itself was not really harmed by such influences. In the following groups, such is no longer the case. We here think at first of those severe injuries which have their sources in abnormal processes outside of the brain. The anaemia of the patient or the low state of his nutrition or the fever heat of his blood impairs the harmony of the mental functions. Another and for the psychotherapist much more important group is that in which the impairment results from toxic influences. Alcohol, morphine, cocaine, tobacco, and many other drugs may have been misused and may have produced a most marked alteration in the mind-brain system. Desires may have developed which completely destroy the balance of the normal functions and yet the satisfaction of which increases the poisoning effect. But here belongs further the effect of poisons which the body itself produces: the toxic disturbance of uraemia or the coma in diabetes, or especially the grave disturbances resulting from the abnormal action of the thyroid gland, the source of cretinism. Many indications suggest that a near future will consider this group much larger than we are really justified in doing today, probably soon connecting a number of other mental diseases like dementia praecox with toxic effects of bodily origin. Experience shows that in this group not a few chances exist for successful psychotherapeutic influence. Yet the means may be various in character and their effect may be a direct or an indirect one. A psychical shock may remove directly the mental disturbance of the alcoholic state, but it is more important that mental suggestion can remove the alcoholic disturbance indirectly by suppressing the desire for alcoholic excesses. Even where cure by psychotherapeutic means is out of the question, as is the case with feverish delirium or uraemic excitements, no skilled physician ignores the aid which a well-adjusted mental influence can offer to the patient.