We come to a third group. Some outside cause has harmed the central nervous system directly, and has left it in a disabled state after the cause itself has disappeared. Such causes may have been at first purely functional: for instance, a neglect of training, or a wrong training, or an over-activity, but the ill-adjusted function which involved, of course, every time an ill-adjusted organic activity or lack of activity, has led to a lasting or at least relatively lasting disturbance in the system of paths. The neglect of training, for instance, in periods of development may have resulted in the retardation which yields the symptoms of a feeble-minded brain, or the wrong training may have created vicious habits, firmly established in the mind-brain system and gravely disturbing the equilibrium. Above all, the overstrain of function, especially of emotional functions, may lead to that exhaustion which produces the state of neurasthenia. It is true that not a few would doubt whether we have the right to class neurasthenia here where we speak of the harm done to the normal brain. Many neurologists are inclined to hold that neurasthenia demands a special predisposition and is therefore dependent upon a neurotic constitution of the brain itself. But if defenders of such a view, as for instance, Dubois, acknowledge that "we might say that everybody is more or less neurasthenic," we can no longer speak of any special predisposition. Certainly there exists a constitutional neurasthenia sometimes but we have hardly a right to deny that overstrain in the brain activity may produce a series of neurasthenic symptoms in any brain, and the special predisposition is responsible rather for the particular selection among the innumerable symptoms. Neurasthenia certainly is the classical ground for the psychotherapist. The patient's insomnia and his headache, his feeling of tiredness and his disgust with himself, his capricious manias and his absurd phobias, his obsessions and his fixed ideas all may yield to the "appeal to the subconscious," and as a neurasthenic easily believes in the existence of various organic diseases in his body, Christian Science can perform here even "miracles." In the case of retardation, the psychical influence will have to be in the first place one of training. Yet it would be narrow to overlook that in neurasthenia, too, suggestion has to be only a part of the psychical treatment. Training and rest, distraction and sympathy and many other factors have to enter into the plan. Incomparably small, on the other hand, is the aid which psychotherapy can offer in cases of real destructions in the brain, as in the case of tumors, hemorrhage, paresis or the degeneration by senility. More effective may be its work in concussion of the brain and especially with traumatic neuroses, as in the case when a railroad accident has put the mind-brain system out of gear.