The cost and drain of men for the enterprise had been very great. The fame of the discovery had rung through the world, and had exalted Isabel and Castile as they had never been exalted before, but up to this period the returns in money had been insignificant, whilst the unsettling influence of the adventure upon the nation at large had been very injurious. Ferdinand, for reasons already explained, always regarded it coldly; and the loss of Ovando’s fleet seemed to prove him right. When, therefore, Colon begged for the Queen’s aid to sail with a fourth expedition early in 1502, she was unwilling to help; though she was sufficiently his friend still to prevent others from hindering him; and he sailed for the last time in March 1502, to see his patroness no more; for when he came back, two years and nine months later, broken with injustice, and with death in his heart, Isabel the Catholic was dead. Even greater sorrows than those of America came to Isabel in her last years, troubles that stabbed her to the very heart, and from which one of the great tragedies of history grew. From Flanders came tidings of grave import for the future of the edifice so laboriously reared by Ferdinand and Isabel. The heiress of Spain, the Archduchess Joan, with her cynical, evil-minded husband, Philip the Handsome, were daily drifting further away from the influence of Joan’s parents. Dark whispers of religious backsliding on the part of the Court of Brussels were rife in the grim circle of friars and devotees that accompanied Isabel. It was said that Joan and her husband openly slighted the rigid observance of religious form considered essential in Spain, and that the freedom of thought and speech common in Flanders was more to the taste of Joan than the terror-stricken devotion of her Inquisition-ridden native land. Isabel had dedicated her strenuous life and vast ability to the unification of the faith in Spain. She had connived at cruelty unfathomable, and had exterminated whole races of her subjects with that sole object. Throughout her realms and those of her husband no heresy dared now raise its head, or even whisper doubt; and the thought that free-thinking, mocking Burgundian Philip, with his submissive wife, so alienated from her own people that she refused to send a message of loving greeting to her mother, should come and work their will upon the sacred soil of Castile, must have been torture to Isabel. To Ferdinand it must have been as bad; for it touched him, too, in his tenderest part. His life dream had been to realise the ambitions of Aragon. For that he had plotted, lied, and cheated; for that he had plundered his subjects, kept his realms at war, bartered his children and usurped his cousin’s throne. But it would be all useless if Castile slipped through his fingers when his wife died, and his deadly enemy, his son-in-law, became king of Castile in right of his wife Joan.