It was not very easy to apply the methods of the laboratory to the preliminary treatment of the residue in the factory. M. Debierne investigated this question, and organised the treatment in the factory. The most important point of his method is the conversion of the sulphates into carbonate by boiling the material with a concentrated solution of sodium carbonate. This method avoids the necessity of fusing with sodium carbonate. The residue chiefly contains the sulphates of lead and calcium, silica, alumina, and iron oxide. In addition nearly all the metals are found in greater or smaller amount (copper, bismuth, zinc, cobalt, manganese, nickel, vanadium, antimony, thallium, rare earths, niobium, tantalum, arsenic, barium, &c.). Radium is found in this mixture as sulphate, and is the least soluble sulphate in it. In order to dissolve it, it is necessary to remove the sulphuric acid as far as possible. To do this, the residue is first treated with a boiling concentrated soda solution. The sulphuric acid combined with the lead, aluminium, and calcium passes, for the most part, into solution as sulphate of sodium, which is removed by repeatedly washing with water. The alkaline solution removes at the same time lead, silicon, and aluminium. The insoluble portion is attacked by ordinary hydrochloric acid. This operation completely disintegrates the material, and dissolves most of it. Polonium and actinium may be obtained from this solution; the former is precipitated by sulphuretted hydrogen, the latter is found in the hydrates precipitated by ammonia in the solution separated from the sulphides and oxidised. Radium remains in the insoluble portion. This portion is washed with water, and then treated with a boiling concentrated solution of carbonate of soda. This operation completes the transformation of the sulphates of barium and radium into carbonates. The material is then thoroughly washed with water, and then treated with dilute hydrochloric acid, quite free from sulphuric acid. The solution contains radium as well as polonium and actinium. It is filtered and precipitated with sulphuric acid. In this way the crude sulphates of barium containing radium and calcium, of lead, and of iron, and of a trace of actinium are obtained. The solution still contains a little actinium and polonium, which may be separated out as in the case of the first hydrochloric acid solution.