The full investigation of these changes will be shown to verify in every particular the hypothesis that radio-activity is the accompaniment of chemical changes of a special kind occurring in matter, and that the constant activity of the radio-elements is due to an equilibrium process, in which the rate of production of fresh active matter balances the rate of change of that already formed. The nature of the process taking place in the radio-elements, in order to give rise to the production at a constant rate of new kinds of active matter, will now be considered. Since in thorium or uranium compounds there is a continuous production of radio-active matter, which differs in chemical properties from the parent substance, some kind of change must be taking place in the radio-element. This change, by which new matter is produced, is very different in character from the molecular changes dealt with in chemistry, for no chemical change is known which proceeds at the same rate at the temperatures corresponding to a red heat and to liquid air, and is independent of all physical and chemical actions. If, however, the production of active matter is supposed to be the result of changes, not in the molecule, but in the _atom itself_, it is not to be expected that the temperature would exert much influence. The general experience of chemistry in failing to transform the elements by the action of temperature is itself strong evidence that wide ranges of temperature have not much effect in altering the stability of the chemical atom.