401. In the treatment of _Intermittent Fever_ this remedy ranks next to Quinine, over which it possesses the advantage of being comparatively cheap, and, from its being manufactured in India, is within the reach of all. It has its disadvantages, however, being apt to create nausea, vomiting, with a burning sensation at the pit of the stomach, extending, in some instances, to the throat, and occasionally diarrhœa. Like Quinine, if given in sufficient doses to produce its specific effect, it gives rise to headache, singing in the ears, giddiness, and other symptoms included under the term "Quinism;" but all these pass away on the discontinuance of the remedy, leaving no after ill effects. It is, in fact, a thoroughly safe and efficacious remedy in ordinary simple Intermittents, but its use is limited to these. In the severer forms and in Remittent Fevers it is not to be depended upon: here Quinine remains the sheet anchor. The dose is from 5 to 10 grains twice or thrice daily during the intermission or in anticipation of an expected paroxysm. Dilute Sulphuric Acid (one and a half minim to one grain of the alkaloid) is said to be the best solvent, but given with Dilute Hydrochloric or Citric Acid, its disagreeable taste and smell are partially masked, and hence is more easily borne. Fresh Lime Juice is recommended as an eligible vehicle for popular use. 402. _In Debility after Fevers_ it promises to be of great value as a tonic, given in small doses. It is worthy of a trial in _Enlargement of the Spleen_ in combination with Sulphate of Iron (176). In _Neuralgia_, _Faceache_, _Tic Douloureux_, when assuming a periodical form, this remedy is well worthy of a fair trial. It should be given in full doses (10 grains) thrice daily for adults.