II. INSENSIBILITY, generally following nervous excitement. Morphia and opium; henbane (_Hyoscyamus_); stramonium; belladonna; nicotine (_tobacco_); darnel (_lolium temulentum_); hemlock (_Conium maculatum_); water hemlock (_Œnanthe crocata_); fool’s parsley (_Æthusa cynapium_), [Dr. J. Harley shows that this is not so poisonous as believed: _see_ St. Thomas’s Hospital Reports, x. 25]; Indian hemp (_Cannabis indica_); Woody Nightshade (_Solanum dulcamara_); Solanum nigrum; the berries of Potato (_Solanum tuberosum_); Lobelia inflata: Foxglove (_Digitalis_); cocculus indicus; certain fungi (notably _Amanita muscaria_); chloroform; chloral; butylchloral —“croton chloral”): amylene; methylene dichloride; sulphuretted hydrogen; carbonic oxide; and many other substances usually classed as _narcotics_. III. VOMITING.—Irritant poisons, such as acids, alkalies, alkaline salts in considerable doses (even common salt has proved fatal: _see_ Christison[1]); most soluble compounds of the heavy metals (especially antimony, arsenic, zinc, and copper); certain vegetal alkaloids (from colchicum, laburnum, yew, savin, ipecacuanha, capsicum, pepper, ergot, many species of Ranunculaceæ, the Hellebores, and some fungi); cantharides, turpentine, and essential oils, &c. Pain in the digestive organs, purging, and general inflammation are commonly present. Most of the medicinal purgatives will produce sickness and vomiting if given in overdoses; of course unwholesome food or disease may frequently be the cause. IV. ACTION ON THE EYE.—Opium and morphia, calabar bean, aconite (?), and strychnia, _contract_ the pupil: belladonna, henbane, tobacco, stramonium, digitalis and hemlock, _dilate_ the pupil. The effect is often temporary, and sometimes is reversed after a time. It is a valuable indication in after-experiments on animals. V. CONVULSIONS.—Strychnia, brucia, and some fungi: but this symptom is by no means confined to these, and may even result as tetanus, from disease or irritants (_see_ Trial of Palmer). Morphia, in rare cases, has also caused it. VI. CHRONIC POISONING, prostration and wasting. Antimony, mercury, and lead in small repeated doses. With the two latter, but more especially with lead, there is a _blue line at the edge of the gums_; constipation and colic, paralysis and trembling of the limbs. As lead frequently occurs as an impurity in food, and also may be absorbed by those working with it, these symptoms may be often accidental. Mercury also is given, less than of old, it is true, but still systematically by some, as a regular course in syphilis, &c.: also to children in teething powders. Antimony has been almost abandoned in medicine, from its depressant effect. In these cases, motive, amount, and necessity of dose, and right to administer, must be considered before wilful poisoning can be proved. The analysis, therefore, must be strictly _quantitative_, which is fortunately tolerably easy.