Response in the Living and Non-LivingBose, Jagadis Chandra
Science
Response in the Living and Non-Living
Bose, Jagadis Chandra
Electrophysiology; Fatigue; Irritability
#Action current.#--We have seen that a current of injury--sometimes known
as 'current of rest'--flows in a nerve from the injured to the
uninjured, and that the injured B is then less excitable than the
uninjured A. If now the nerve be excited, there being a greater effect
produced at A, the existing difference of potential may thus be reduced,
with a consequent diminution of the current of injury. During
stimulation, therefore, a nerve exhibits a negative variation. We may
express this in a different way by saying that a 'current of action' was
produced in response to stimulus, and acted in an opposite direction to
the current of injury (fig. 2, _b_). The action current in the nerve _is
from the relatively more excited to the relatively less excited_.
#Difficulties of present nomenclature.#--We shall deal later with a
method by which a responsive current of action is obtained without any
antecedent current of injury. 'Negative variation' has then no meaning.
Or, again, a current of injury may sometimes undergo a change of
direction (see note, p. 12). In view of these considerations it is
necessary to have at our disposal other forms of expression by which
the direction of the current of response can still be designated.
Keeping in touch with the old phraseology, we might then call a current
'negative' that flowed from the more excited to the less excited. Or,
bearing in mind the fact that an uninjured contact acts as the zinc in
a voltaic couple, we might call it 'zincoid,' and the injured contact
'cuproid.' Stimulation of the uninjured end, approximating it to the
condition of the injured, might then be said to induce a cuproid
change.
The electric change produced in a normal nerve by stimulation may
therefore be expressed by saying that there has been a negative
variation, or that there was a current of action from the more excited
to the less excited, or that stimulation has produced a cuproid
change.
The excitation, or molecular disturbance, produced by a stimulus has
thus a concomitant electrical expression. As the excitatory state
disappears with the return of the excitable tissue to its original
condition, the current of action will gradually disappear.[3] The
movement of the galvanometer needle during excitation of the tissue thus
indicates a molecular upset by the stimulus; and the gradual creeping
back of the galvanometer deflection exhibits a molecular recovery.
This transitory electrical variation constitutes the 'response,' and its
intensity varies according to that of the stimulus.
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