Heartless monstrosities (_Acardiaci_) are, in spite of imperfect nutrition (the conditions of proper nutrition by the blood are wanting in the embryo), of the same sex as normal offspring. Now, cases of this kind demonstrate that, in the later periods of development, although the conditions of nutrition are not alike, nevertheless the similarity of sex in the twins is maintained; so the foundation of the future sex would be laid at the period of conception. This rule which proves valid for the twins found in a single chorion, would apply for all human ova in general, because all possess the capacity of attaining their sexual character at conception. According to Mayrhofer, placentæ are rare in which, where there are two chorions, communication is found between the vessels of the two umbilical cords. In addition to what has been already mentioned, Mayrhofer lays down the law, which we find frequently stated in many quarters, that the older of the two parents has a greater preponderance in favor of the propagation of his, or her, sex. Especially the physical maturity on the man’s side enables him to propagate his own sex, either in connection with younger or older women. A superiority on the part of the woman produces girls. Our author only partly supports Thury’s theory, and considers it an open question whether the time of impregnation has any influence on the origin of sex. But he lays down this principle, that an economy of the semen by infrequent indulgence in intercourse is extremely favorable to the production of males. It may be possible to obtain more exact data respecting the origin of sex from the artificial breeding of fish. In this case the properties of the sperm, as well as of the ova, might be observed at an earlier date by means of a fertilization effected externally. Attention might be also paid to the age of the parents. In short, all the factors of artificial influence upon the development of sex can in this case be taken in hand and controlled by varying the process of artificial fertilization. The author does not appear to know that the results obtained by artificial breeding differ remarkably from those which are the consequence of the natural multiplication of fish, nor that the development of sex is unfavorably affected in many ways. The cause of that lies very likely in the nutrition of the young fry, and perhaps, also, partly in cross-breeding. What influence the physical welfare of the parents, and especially of the mother, has on the sex of the offspring in man, besides other factors deserving of attention, ought to be discoverable from the statistics of the lying-in hospitals. This is, in my opinion, hardly to be expected. * * * * *