In fact, I found that the urine of most women who had male offspring contained, during the first months of pregnancy, more reducing substances than the urine of women who had female offspring. It is, therefore, also necessary that the diet should not only occasion a disappearance of the normal urine-sugar, but should also produce an increase of the reducing substances. This end can be accomplished certainly also by the use of different medicines, such as chloroform, turpentine, salicylic acid, etc. But, apart from the fact that medicinal influences are distinctly to be discouraged, these substances do not seem to produce the same effects as diet. Besides, it is still a question of what kind these efficient substances are. And another question is whether they are themselves effective. It will be sufficient for us to recognize them as a symptom. It is known that the male sex possesses a distinctly greater amount of albumen than the female. In age this difference disappears; in youth it is greater. It might be expected that male offspring would result, in consequence of a more albuminous diet, by which a greater increment of albumen would be made possible; the thing, however, is not quite so simple as this. Investigations in various cases showed me that women in whom an increased amount of albumen could be detected, but in whom either sugar was present to a small extent, or, on the other hand, only very small quantities of reducing substances could be detected, almost always had female offspring. In spite of many endeavors to elucidate this phenomenon, I was forced to have recourse to the symptoms alone, and to hope for the production of the male sex only from the disappearance of the sugar and the increase of the reducing substances. Certainly, further investigations showed that the same diet which was the most favorable to the production of the condition which I have named (the disappearance of the sugar from the urine and the simultaneous increase of the reducing substances), also effected the best albuminous increment in the body. Key’s statements teach us that male individuals put on more albumen than females, and that this is especially the case during the period of growth. Very likely the male embryo also requires a greater amount of albumen than the female, in the same way as this difference exists between the boy and girl. * * * * *