I numbered amongst my acquaintances a family, of whom, in the course of years, I was acquainted with the grandmother, a daughter, and two grand-daughters. The grandmother had, including the third generation, fifteen descendants, of whom twelve were girls and three were boys. Two of the boys were the sons of the grandmother, and the first two children she had borne. She was under medical treatment, and the analysis of the urine showed a considerable quantity of sugar. She had six daughters. One of these daughters, who survived the others, had five children, amongst them one boy, who soon died. Two of the grand-daughters of this family became mothers, each bearing one daughter. I had the opportunity of examining the urine of all the mothers of this family, and always found sugar in it. Sometimes the saccharine contents reached a remarkable quantity, and yet were not such as could be diagnosed to indicate an unhealthy condition. Amongst the acquaintances of my youth was a young lady of good family. Carefully reared, she was, as a child, too much sheltered from the influences of the open air, and in later years much imprisoned in-doors by hard study in different branches of art and science. As a young lady she was fairly tall and well nourished, but pale and possessed of little color. It happened that I had an opportunity of examining this young lady’s urine. As I found a considerable quantity of sugar, I was led to the conclusion that the girl (she was engaged) would have principally female offspring. Many years had elapsed. The young lady had ripened into a stately matron, and told me that she had the happiness to be the mother of five daughters and a son. I am altogether without the statistics necessary to deduce from a great number of similar cases the average relative number of the sexes born of women suffering from diabetes. But this must be pointed out, that, notwithstanding the high percentage of sugar excreted in the case of women suffering from pronounced diabetes, female offspring do not necessarily always appear. They will probably be in a very striking majority when compared with the males, but the complete disappearance of the male sex is not to be anticipated, because male individuals, though in the minority, can appear. And this was to be anticipated, seeing that in the so-called slighter cases of this complaint the abnormal metabolism can be sensibly improved by attention to diet. * * * * * Diabetes amongst women has a marked influence upon the functions of the sexual organs. Thus, for example, the menses cease, a condition which, according to gynæcologists, is occasioned by an abnormal condition of the womb and of the ovaries which become atrophied. (Schauta.) On the other hand, diabetes may also result from diseases of the reproductive organs. (Imlach.) When the cause of the complaint is removed from the female genitals the sugar also disappears from the urine.