From this moment until its first application to the extraction of a tooth you can well imagine my suspense. That I might not fail in the very first attempt, I compelled myself and others in my household to breathe rapidly to investigate the phenomenon. This gave me some idea as to the proper method of proceeding in its administering. The first case soon appeared, and was a perfect success, going far beyond my anticipations, for the effect was such as to produce a partial paralysis of the hands and arms to the elbow. Again and again I tried it in every case of extraction and many other experiments, doubting my own senses for a long time at a result so anomalous and paradoxical. I was reminded just here of a phenomenon which gave me additional proof--that of blowing a dull fire to revive it. For a minute or so one blows and blows in rapid succession until, rising from the effort, a sense of giddiness for a few moments so overcomes that the upright position is with difficulty maintained. In this condition you are fitted for having a tooth extracted or an abscess lanced. Believing that I had something new to offer which might be of use to suffering humanity, I read the first article upon it Nov. 17, 1875, before the Franklin Institute. Shortly after I was invited before the Northern Medical Society of this city to address them thereon. A number of medical gentlemen have been using it in their practice, while the bulk of them have spurned it as "negative" and preposterous, without an effort at trying it, which I can _now_ very well understand. Unless one is aware of the fact that in the use of any agent which has the power to suspend the volition, it can be taken to that point where he is still conscious of _touch and hearing_, and at the same time not cognizant of pain inflicted, the action of rapid breathing could not be understood. And I regret to say that of three-fourths of the medical men I have talked with on the subject they had not been aware of such a possibility from ether and chloroform. Until this analgesic state could be established in their minds it was impossible to convince them that the excess of oxygen, as obtained by rapid breathing, could be made to produce a similar effect. _I_ should have been as reluctant as any one to believe it, had I not personally experienced the effect while performing an operation which would otherwise have been very painful. Such a result could not well be reached by any course of reasoning.