Has it proven in my practice what has been claimed for it--a substitute for the powerful anaesthetics in minor operations in surgery? Most emphatically, yes! So completely has it fulfilled its humble mission in my office, that I can safely assert there has not been more than five per cent. of failures. I have given it under all circumstances of diseased organs, and have seen no other than the happiest results in its after effects. It may well be asked just here: Why has it not been more generally and widely used by the dental profession as well as the medical, if it is really what is claimed for it? The most satisfactory and charitable answer to be given is, the failure upon their part to comprehend the _fact_ as existing in chloroform and ether that there is such a state as analgesia; or, in other words, that the animal economy is so organized, while the sense of touch is not destroyed, but rather increased, the mind of the subject fails to perceive a sense of pain when anaesthetics are given, and the effects are manifested in the primary stage. As I before intimated, such is the knowledge possessed by most of those who administer ether and chloroform. This was enough to cause nearly every one to look upon it as a bubble or air castle. Many gentlemen told me they tried it upon themselves, and, while it affected them very seriously by giddiness, they still _retained consciousness_; and, such being the case, no effect could be produced for obtunding pain. Others told me they were afraid to continue the breathing alarmed at the vertigo induced. And the practitioner who has adopted it more effectively than any other laughed at me when I first told him of the discovery; but his intimate association with me changed his views after much explanation and argument between us. It was hardly to be expected that without this knowledge of analgesia, and without any explanation from me as to the _modus operandi_ of rapid breathing, other than a few suggestions or directions as to how the effect was induced, even the most liberal of medical men should be able to make it effective, or have the least disposition to give it a preliminary trial upon themselves, and, of course, would not attempt it upon a patient. Notwithstanding, it found a few adherents, but only among my personal _medical_ friends, with whom I had an opportunity to explain what I believed its physiological action, and the cases of success in my own practice. To this I have submitted as among the inevitable in the calendar of discoveries of all grades. My own profession have attempted to _ridicule_ it out of its birthright and possible existence, which style of argument is not resorted to by true logicians.