The heart's action is not increased more than from seventy (the average) to eighty and sometimes ninety, but is much enfeebled, or throwing a lesser quantity of blood. The face becomes suffused, as in blowing a fire or in stooping, which continues until the breathing is suspended, when the face becomes paler. (Have not noticed any purple as from asphyxia by a deprivation of oxygen.) The vision becomes darkened, and a giddiness soon appears. The voluntary muscles furthest from the heart seem first to be affected, and the feet and hands, particularly the latter, have a numbness at their ends, which increases, until in many cases there is partial paralysis as far as the elbow, while the limbs become fixed. The hands are so thoroughly affected that, when open, the patient is powerless to close them and _vice versa_. There is a vacant gaze from the eyes and looking into space without blinking of the eyelids for a half minute or more. The head seems incapable of being held erect, and there is no movement of the arms or legs as is usual when in great pain. There is no disposition on the part of the patient to take hold of the operator's hand or interfere with the operation. Many go on breathing mechanically after the tooth is removed, as if nothing had occurred. Some are aware that the tooth has been extracted, and say they felt it; others could not tell what had been accomplished. The majority of cases have an idea of what is being done, but are powerless to resist. With the very intelligent, or those who stop to reason, I have to teach them the peculiarities of being sensible of touch and not of pain. One very interesting case I will state. In extracting seven teeth for a lady who was very _unwilling_ to believe my statement as to touch and no pain, I first removed three teeth after having inhaled for one minute, and when fully herself, she stated that she could not understand why there was no pain while she was conscious of each one extracted; it was preposterous to believe such an effect could be possible, as her reason told her that there is connected with tooth extracting pain in the part, and of severe character, admitting, though, she felt no pain. She allowed one to be removed without anything, and she could easily distinguish the change, and exclaimed, "It is all the difference imaginable!" When the other three were extracted, there was perfect success again as with the first three. One of the most marked proofs of the effects of rapid breathing was that of a boy of eleven years of age for whom I had to extract the upper and lower first permanent molars on each side. He breathed for nearly a minute, when I removed in about twenty seconds all four of the teeth, without a moment's intermission or the stopping the vigorous breathing; and not a murmur, sigh, or tear afterward. He declared there was no pain, and we needed no such assertion, for there was not the first manifestation from him that he was undergoing such a severe operation.