Another case, the same day, when I had to extract the superior wisdom teeth on both sides for an intelligent young lady of eighteen years, where I had to use two pairs of forceps on each tooth (equivalent to extraction of four teeth), and she was so profoundly affected afterward that she could; not tell me what had been done other than that I had touched her four times. She was overcome from its effects for at least a minute afterward. She was delighted. With such severe tests I fear very little the result in any case I can have them do as I bid. There can be no mistake that there is a _specific action_ from something. It cannot be personal magnetism or mesmeric influence exerted by me, for such cases are rare, averaging about 10 per cent, only of all classes. Besides, in mesmeric influence the time has nothing to do with it; whereas, in my cases, it cannot last over a half minute or minute at most. It cannot be fear, as such cases are generally more apt to get hurt the worse. It is not diversion of mind alone, as we have an effect above it. There is no better way of testing whether pain has been felt than by taking the lacerated or contused gums of the patient between the index finger and thumb and making a gentle pressure to collapse the alveolar borders; invariably, they will cry out lustily, _that is pain_! This gives undoubted proof of a specific agent. There is no attempt upon my _own_ part to exert any influence over my patients in any way other than that they shall believe what I say in regard to _giving_ them _no pain_ and in the following of my orders. Any one who knows how persons become mesmerized can attest that it was not the _operator who forces them under it against their will_, but it is a peculiar state into which any one who has within themselves this temperament can _place_ themselves where any one who knows how can have control. It is not the will of the operator. I therefore dismiss this as unworthy of consideration in connection with rapid breathing. Then you may now ask, To what do I attribute this very singular phenomenon? Any one who followed, in the earlier part of this paper, the course of the argument in my soliloquy, after twenty years had elapsed from my observation upon myself of the analgesic effects of chloroform, can almost give something of an answer. That you may the more easily grasp what I shall say, I will ask you, If it be possible for any human being to make one hundred inhalations in a minute and the heart's action is not increased more than ten or twenty pulsations over the normal, what should be the effect upon the brain and nerve centers?