Many years ago it was very much the custom to administer large doses of powdered Peruvian bark. The rationale of these large doses was founded upon their sedative effect. Haygrath, Morton, Heberden, and Fothergill were the first to employ this method. Later still, a number of noted French physicians, among them Briquet, Andral, Monerat, and Legroux, renewed the use of this medicine in the form of quinia, but gave it in smaller doses, seeking only its tonic effect, from five to fifteen grains being administered in the course of twenty-four hours, and then it was still continued in smaller doses. Still more recently, quinia taking the place of Peruvian bark, the old plan of administering large doses has been resumed. From thirty all the way up to one hundred grains have been administered in the course of twenty-four hours. Never was there a more profligate waste of a precious medicine. Even the physicians who so used it were obliged to acknowledge that it only did good in sub-acute and mild cases. I believe that it has also been fashionable in the so called cases of hyperpyrexia to immerse the patient in a bath varying in temperature from 60° to 98° Fahr. Although patients thus treated sometimes recovered, they also sometimes perished from congestion of the lungs and brain. Among cardiac and nervous sedatives, digitalis, veratrum album and viride, veratria and aconite, have each, at one time or other, been employed indiscriminately. Such treatment, of course, has only proven itself to be a monument of rashness to those who employed it. Such sedatives may reduce the pulse, but do not shorten the disease. Indeed, if it is possible to prove the absurdity of anything more clearly by mere enumeration of these medicines as cures for rheumatism, I do not know of it. Do digitalis and aconite act in the same manner? This is just one expression of the folly which surrounded the use of digitalis at the time of its discovery. Then every affection of the heart was treated with digitalis.