Within the last few years new remedies have been proclaimed in the shape of salicylic acid and its sodium salt. I confess that I possess no personal knowledge of their use in this disease, for I was at first dissuaded from employing them by a prejudice against the grounds on which they were recommended, and more recently by the contradictory judgments respecting them, and the unquestionable mischief they have sometimes caused. According to their eulogists, the arrest of the disease is secured by them within four or five days, whether the attack be febrile or not; its mortality was diminished; relapses do not occur if the medicine is continued until full convalescence; it is without influence on the heart complications already existing, but it tends to prevent them as well as other serious inflammations. One of these gentlemen assures us that to say it far excels any other method of treatment would be to give it but scant praise. But, upon the other hand, it is accused of producing disorders, and even grave accidents in almost all the functions of the economy. In some cases it has produced ringing in the ears or deafness, or a rapid pulse, or an excessively high temperature, panting respiration, profuse perspiration, albuminuria, delirium, and imminent collapse. In one published case this anti-pyretic did not lower, but, on the contrary, seemed actually to raise the temperature so high that immediately after death it stood at 110° F. Many, very many, analogous cases have been published. I repeat, therefore, that I am personally unacquainted with the effects of this medicine in acute articular rheumatism, and that I have not thus far been tempted to employ it. It may be difficult to see the connection between blisters and alkalies in their power to influence the course of acute articular rheumatism, and yet it is certain that they do so influence it, and in the same way, _i. e._, by altering the condition of the blood from acid to alkaline. If you ask me to explain to you how blisters act in this way I am obliged to confess my ignorance. To produce this result they must be applied over all the affected joints. Experience, if not science, has decided conclusively in their favor. They do effect a cessation of the local symptoms, render the urine alkaline, and diminish the amount of fibrin in the blood.