Of this I have no direct evidence as yet, but it is a point of considerable interest, and I may possibly return to it at some future time.--_Chemical News._ * * * * * CHINOLINE. Dr. Conrad Berens, of the University of Pennsylvania, reaches the following: 1. Chinoline tartrate is a powerful agent, producing death by asphyxia. 2. The drug increases the force and frequency of the respirations by stimulating the vagus roots in the lung. 3. It paralyzes respiration finally by a secondary depressant action upon the respiratory center. 4. It does not cause convulsions. 5. It lessens and finally abolishes reflex action by a direct action upon the cord, and by a slight action upon the muscles and nerves. 6. It diminishes or abolishes muscular contractility respectively when applied through the circulation or directly. 7. It coagulates myosin and albumen. 8. It causes insalivation by paralysis of the secretory fibers of the chorda tympani; increases the flow of bile; has no action upon the spleen. 9. It lowers blood-pressure by paralyzing the vaso-motor centers and by a direct depressant action upon the heart muscle. 10. It diminishes the pulse rate by direct action upon the heart. 11. It lowers the temperature by increasing the loss of heat. 12. It is a powerful antiseptic; and, finally, 13. Its paths of elimination are not known. * * * * * METHOD FOR RAPID ESTIMATION OF UREA. Being called upon to make a good many brief and rapid analyses of urine on "clinic days" of our medical department, I devised the following modification of Knop's method of estimating urea; and after using it for a year with perfectly satisfactory results, venture to describe and recommend it as especially adapted for physicians' use, by reason of simplicity, cheapness, and accuracy. In perfecting and testing it I was assisted greatly by J. Torrey, Jr., then working with me. [Illustration] The apparatus consists of the glass tube, A, which is about 8 cm. long and 21/2 cm. in diameter, joined to the tube, B, which is about 25 or 30 cm. in length in its longer arm and 8 or 10 in its shorter, and has a diameter of about 5 mm. Near the bend is an outlet tube, _c_, provided with "ball valve" or pinch cock. _d_, _e_, _f_, _g_, are marks upon the tubes. C is a rubber cork with two holes through which the bent tube, D, passes. D is of such size and length as to hold about 1 c.c., and one of its ends may be a trifle longer than the other.