Bischoff, Voit, and Hermann have shown that water increases, not alone the elimination of urine, but also of sodium chloride, phosphoric acid, etc. Grigoriantz observed augmentation of disintegration when the quantity of beverage exceeded forty-six to eighty ounces ("1,400 to 2,400 cubic centimeters") per diem. Oppenheim, Fraenkel, and Debove, while believing water has but little influence upon the exchanges, admit it certainly need not diminish the latter; and Debove and Flament, after administering water in quantities varying from two to eight pints per diem, concluded that urine was diminished below the former figure, while above the latter it increased somewhat, being dependent upon the amount ingested. It was on the strength of the foregoing that Lallemand declared water to have no influence upon the exchanges. The results claimed by Oppenheim, Debove, et al. were immediately challenged--and it is now generally admitted, not without some justice--by Germain See. It seems certain, to say the least, that water taken during the repast does tend to augment the quantity and facilitate the elimination of urine. Abundance of beverage, moreover, presents other advantages, in that it facilitates digestion by reason of its diluent action, a fact well worth bearing in mind when treating the obese who are possessed of gouty diathesis, and whose kidneys are accordingly encumbered with uric and oxalic acids. The foregoing presents the ground upon which Germain See permits an abundance of beverage; but he also expresses strong reservation as regards beer and alcohol, either of which (more especially the former) tends to the production of adipose. In his opinion, the only beverage of the alcoholic class that is at all permissible, and then only for cases suffering from fatty heart, is a little _liqueur_ or diluted wine. Coffee and tea he commends highly, and recommends the ingestion of large quantities at high temperature, both during the repasts and their intervals. Coffee in large doses is undoubtedly a means of de-nutrition, and so, too, in no less extent, is tea; both act vigorously owing to the contained alkaloids, though, to be sure, they sometimes, at first, tend to insomnia and palpitation, to which no attention need be paid, however. The treatment outlined by See is: 1. A physiological regimen comprising four to five ounces of nitrogenous principles as derived from eight to ten ounces animal muscle and albuminates; three to six ounces of fat; eight to ten ounces of hydrocarbons as yielded by ten to twelve ounces of sugar or starch food. These proportions to be modified in such manner that the musculo-albuminates shall not sensibly exceed the normal ratio, for meat in excess itself furnishes fat during transformation. The fatty substances of easy digestion may, without inconvenience, be utilized in doses of two to three ounces. The hydrocarbons should be reduced to a minimum. As for the herbaceous elements, they contain nothing nutritive.