In 1871 Ingerslev, an assistant of Hirschsprung in Copenhagen, wrote a
paper on "A Case of Scurvy in a Child," which is quite convincing. Two
years later Jalland, an English physician, reported a similar case of
"Scurvy in a Ten-Months-Old Infant." In 1878 Cheadle reported three
cases of infantile scurvy with typical tumefaction of the gums, and
obscure tenderness of the legs, and followed this paper by two others,
which appeared in 1879 and 1882. Cheadle clearly recognized the disease
as scurvy. However, as the title of his first paper--"Three Cases of
Scurvy Supervening on Rickets in Young Children"--indicates, he
considered it a condition engrafted upon rickets. About this time (1881)
Gee presented a brief but accurate account of five cases of scurvy which
he termed "osteal or periosteal cachexia."
In 1883, Barlow published his classical paper on this subject, the first
to furnish anatomical proof that this disorder of infants presented the
pathological changes characteristic of adult scurvy. Previous to this
publication there had been but one autopsy report, that by Moeller,
which had been incorrectly interpreted. The work of Barlow was accepted
remarkably quickly in England and in America, but less promptly on the
Continent. This was probably due to the fact that infantile scurvy was
occurring far more frequently in these two countries, and that the
subject was open therefore to more prompt investigation. This increased
prevalence of infantile scurvy in the two great English-speaking nations
has continued to the present time, and no doubt is due to the extensive
employment of artificial feeding and of proprietary foods. In 1894 not
less than 106 cases were reported to the Academy of Medicine of New York
City by various physicians, and in 1898 the comprehensive investigation
of the American Pediatric Society appeared, which was based on 379
cases.
It was soon evident that infantile scurvy occurred to a greater or less
degree throughout the civilized world. In France, Monfalcon had reported
a case in 1820 which is sometimes referred to as the earliest case of
infantile scurvy mentioned in the literature. It relates, however, to an
older child and was published as a case of scorbutic rickets. Netter
was one of the first in France to recognize the true nature of the
disorder, and published several papers in 1898 describing typical cases.
Infantile scurvy was, however, almost unknown in that country until what
is termed "lait maternisé" and "lait fixé" came into vogue. This is
apparent from a table prepared by Lecornu, which gives a list of all
cases in the French literature between 1894 and 1904, and of the diets
on which they came about. The former of these milk preparations is
subjected to various manipulations and then heated to a temperature
above the boiling point; the latter is shaken violently in a machine to
render the fat globules smaller, and is then sterilized by one of the
usual methods.
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