I want, if possible, the patient to use his own endeavours to try and keep off alcohol during the first few days of treatment; if this cannot be done, then the treatment must be commenced when the patient is not drinking, in order to give the medicine a better hold on the system. The dislike for alcohol, which we claim, does not come on all at once. The eight days’ treatment is enough to show you that it will do good, but not sufficient in this case to effect a permanent cure. I would advise the patient to continue for at least a month to six weeks. This is somewhat widely at variance with the statements quoted above. “You continue to take your daily modicum of alcohol” and “you will be a free man within a week.” The one guinea “treatment” consisted of 2⅙ fluid ounces of a liquid of the nature of a vegetable fluid extract. The directions were: Half a teaspoonful to be taken in a little water every four hours during the day at 10, 2, 6, and 10 o’c. Analysis showed this to contain 29·3 per cent. by volume of alcohol and 2·3 per cent. of alkaloid, which consisted principally of quinine. The liquid agreed generally with a diluted liquid extract of cinchona; the amount of alkaloid was just under half what is contained in the official liquid extract of cinchona. Treatment with suitable solvents extracted a trace of a non-alkaloidal bitter substance resembling the bitter substances obtainable from quassia, chiretta, &c.; a preparation of chiretta appeared to be the more probable. No strychnine was present, and no evidence was obtained of any other ingredient. SOME OTHER DRUG CURES FOR INEBRIETY. A somewhat frequent constituent of preparations for the treatment of inebriety is atropine, while other preparations contain one or more of the alkaloids belonging to the same group, usually known as the solanaceous alkaloids from the fact that they are all derived from plants of the nat. ord. _Solanaceae_. These alkaloids closely resemble each other in their chemical nature and in their pharmacological properties; the principal members of the group are: Atropine, C₁₇H₂₃NO₃; obtained chiefly from _Atropa belladonna_ (deadly nightshade) and _Scopola carniolica_. Hyoscyamine, C₁₇H₂₃NO₃, obtained chiefly from _Hyoscyamus niger_ (henbane) and _Scopola_ species. Hyoscine, or scopolamine, C₁₇H₂₁NO₄, obtained chiefly from _Scopola_ species, _Hyoscyamus niger_, and _Datura alba_. The two following were originally described as separate substances, but have more recently been shown to consist of mixtures: Duboisine, obtained from _Duboisia myoporoides_, consists chiefly of hyoscyamine and hyoscine. Daturine, from _Datura stramonium_ (thornapple) consists chiefly of hyoscyamine, with a variable proportion of atropine.