The history of outbreaks of scurvy for the last century is practically confined to the experiences of Arctic Expeditions and the campaigning of troops in remote or devastated regions. So little had scurvy been investigated, or any serious study made of the nature of the remedial and preventive action of lime-juice, that up to the year 1914 it was regarded as a matter of course that the acid, the citric acid, of lime-juice was what gave to it its virtue, and samples of lime-juice supplied by contractors were tested solely as to the percentage of that acid present. Eminent medical authorities proposed to use crystals of citric acid in place of the juice; others declared that vinegar would do just as well; others, in spite of the overwhelming record as to the value of lime-juice, held that scurvy was due _not_ to the absence of a food constituent–supplied by fresh vegetables and fruit-juice–but to a peculiar poison present in the salted and dried meat served out as rations; others again, without any study of the disease, have expressed the opinion that it is due to a bacterial micro-organism. A blow to the easy-going belief of the Admiralty that they had mastered and made an end of scurvy was struck when scurvy broke out (60 cases among 122 men) in the expedition to the North Pole which sailed in May 1875 in the _Alert_ and the _Discovery_, under the command of Sir George Nares. The expedition had to return prematurely after seventeen months' absence, and a committee was appointed to inquire into the cause of the outbreak. The stores of food and of lime-juice were shown to have been ample; and the action of the leader in equipping his sledging parties was in accordance with the judgment and experience of successful explorers who gave evidence. The cause of the outbreak remained a mystery. The firm belief in the anti-scorbutic powers of "lime-juice" was shaken, and this unfavourable opinion of its value has been confirmed by medical officers who, during the recent war, have been confronted by outbreaks of scurvy. These outbreaks occurred among troops who, in military circumstances which rendered an adequate supply of fresh meat and vegetables impossible, were supplied with lime-juice prepared from the West Indian "sour-lime." Under these circumstances, an experimental study of scurvy has been carried out during the last four years by a group of workers at the Lister Institute, together with a historical inquiry as to the use of lime-juice. The reports of these investigators have very great practical value and far-reaching interest, as showing what disastrous results may arise from inaccurate use of a word, and the neglect to ascertain the exact nature of the material thing upon which the issue between life and death may depend.