1. Delay time—generally much less than 1 msec
2. Rise time—1 msec or less
3. Magnitude of peak conductance—increases
monotonically with increasing depolarization
4. Inactivation time constant—decreases
monotonically with increasing depolarization.
5. Time constant of recovery from
inactivation—incomplete data
6. Magnitude of steady-state conductance—increases
monotonically with increasing depolarization
7. Fall time on sudden repolarization—less than 1 msec.
Figure 6B shows the potassium conductance change in response to
an imposed step depolarization. Four parameters are sufficient to
characterize this response:
1. Delay time—decreases monotonically with
increasing depolarization
2. Rise time—decreases monotonically with increasing
depolarization
3. Magnitude of steady-state conductance—increases
monotonically with increasing depolarization
4. Fall time on sudden repolarization—8 msec
or more, decreases slightly with increasing
depolarization.
In addition to the aforementioned parameters, the transient portion of
the sodium conductance appears to exhibit an accommodation to slowly
varying membrane potentials. The time constants of accommodation appear
to be those of inactivation or recovery from inactivation—depending on
the direction of change in the membrane potential (18). The remaining
elements in the Hodgkin-Huxley model are constant and are listed below:
1. Potassium potential—80 to 85 mv (inside negative)
2. Sodium potential—45 to 50 mv (inside positive)
3. Leakage potential—38 to 43 mv (inside negative)
4. Leakage conductance—approx. 0.23 millimhos/cm²
5. Membrane capacitance—approx. 1 μf/cm²
6. Resting potential—60 to 65 mv
7. Spike amplitude—approx. 100 mv
ELECTRONIC SIMULATION OF THE HODGKIN-HUXLEY MODEL
[Illustration: Figure 7—System diagram for electronic simulation of the
Hodgkin-Huxley model]
Public-domain text, read in full here on John Shaqi.
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