The clitoris, by some, is supposed to be the seat of irritation, and has been amputated or cauterized, but without generally effecting any relief. The disease is not generally confined to any particular locality of the genitals. If allowed, the patient will take the hand of the male and place it upon the _mons veneris_, and it is only by force that she will allow it to be taken away. She cannot locate the seat of pleasure, but will say that the entire surface touched contributes to the venereal excitement. Another peculiar feature is, that she obtains no satisfaction from venereal orgasm; but on the contrary it adds to her maniacal conduct and obscenity. She is not in any manner responsible for her conduct, and no punishment will cause her to desist. Everything is sacrificed that is feminine, for that which is disgusting and vulgar. The more modest she has been in health, the more obscene she is likely to become in her venereal frenzy. What the final result would be, without treatment, I have never witnessed, but must conclude that lunacy would soon be prominent and probably suicide. There is no tendency to recovery, but to continue from bad to worse, until publicity is no restraint to the obscenity and indecent conduct of the victim. _Case._――Nymphomania, with nocturnal involuntary orgasm. Miss U.――She was aged 19, very small in stature, only weighing 90 pounds, of very respectable family and herself perfectly respectable. She was refused by her probable “intended,” who had discovered signs entirely unnatural for her, in whom he had placed implicit trust. When the condition was first manifested in her, the intended, not thinking of anything wrong on her part, attempted to gratify her morbid erotic desire by coition, which only made her, as he said, “nearly crazy.” She had heretofore been modest and distant, but now she was on his lap, and all over him or leading him to a place of decumbiture. When she visited my office, and imparted to me her whole confidence, my first treatment toward her was so rigid and distant that my examination revealed the parts before orgasm had taken place; but as soon as I touched the nymphæ; they became lubricated with a thin viscid fluid which was profuse. At first the clitoris and nymphæ were red, dry and hot; but as my digit came in contact with the soft parts, she forgot the rough treatment and my cold conduct toward her, which I had assumed to prevent, if possible, her venereal crisis, and she became unmanageable for the time, until she had passed three or four orgasms, as I supposed, one immediately following the other, when she became more governable. To carefully portray in words what she said and did would be shocking to a fastidious doctor. With a speculum in the vagina the os uteri would contract and dilate in alternation, and undergo orgasms in rapid succession, with only a few seconds interval. She begged of me not to withdraw the instrument, but when I had completed my examination she