The general anæmia that so often occurs in spermatorrhœa, caused by impaired digestion and spermal losses, is secondarily the cause of the cerebral anæmia, and tertiarily of softening. The digestive powers, so much impaired by frequent draughts on the vegetative centers, must be a cause for a great disturbance in the nutritive supply of the brain. The vicarious expenditure of nerve-force upon the exaggerated secretory power of the testicles must be a source of great waste, as well as the actual loss of elements, necessary to the structures of a body losing annually by decay. The tendency of local spasm is of no little importance as a cause of local anæmias. Centric irritations, such as influence the _vaso-motor_ centers, without a doubt, cause local spasms of the _vasa vasorum_, capillaries and supplying arterial trunks of organs; and the vessels of the brain are the most likely to be influenced in such a manner, and the tissues of the brain the most likely, of all tissues, to suffer from such a condition. The brain-symptoms do not end with feeble intellection or insanity, but impairment of the special senses and motility is not unfrequently present, as a phenomenon evolved from structural changes in the brain. Asthenopia amblyopia, diplopia, dilatation of the pupil and hyperæsthesia alternated with anæsthesia of the visionary apparatus, aphonia, perversion of the sense of taste, with loss of smell and deafness, are rare yet occasional complications. The usual catalogue of symptoms bears closely to one of two forms, the hyperæmic or anæmic, local or general, of the cerebral substance. The profound impressions wrought upon the minds of these patients by popular sexual literature must greatly exaggerate the structural changes, but are not sufficient of themselves, as a rule, to produce anything but morbid emotions until after enfeeblement has first been organized. The records of the State Asylum, at Utica, N. Y., show five hundred and twenty-one cases admitted directly attributable to this vice; and Dr. Jno. P. Gray, the able superintendent, thinks this greatly understated. Sexual excesses, pollution, and other mismanagements of the sexual functions have received too little attention, and are too seldom mentioned in the etiology of nervous and brain lesions. Too little effort has been put forth to ascertain the proportion of mental diseases caused by the sexual and reproductive organs. A greater number of brain-lesions occurs, in which the sexual function has been a remote cause, than any author, as yet, has ventured to affirm. Statistics of any degree of accuracy are impossible to obtain; but supposition, imagination, and guess-work only can be found to assist in making up a statement of the most important of all causes of disease.