Formula diets would be extremely desirable for short-term flights. A formula diet (a rehydrated liquid formula could be used) would considerably reduce the number of manipulations and the time required for in-flight preparation, compared to a varied diet. These two improvements could contribute materially to the safety of a flight, since the astronauts would not be preoccupied with food preparation for so long a period, and the food could be dispensed without removing suit components, such as gloves. Storage requirements could be simplified with this type of diet. Weight, however, would not be lowered without the development of more refined formulas than those now available. Formula diets could readily be adapted to the determined metabolic requirements of the individual astronaut. Packaging problems will be simplified by using formula diets, which can easily be given a variety of flavors and colors. Waste The problem of waste production is intimately related to nutrition and can be solved or simplified by dietary changes. Any diet should be adjusted for the minimum production of feces, before and during even short flights. Water will be sequestered by accumulation in the feces, and the net loss, under normal conditions, would be approximately 40 to 60 grams per man per day. Flatus can be a serious problem, since considerable concentrations of toxic gases may accumulate. The purification system for the recirculated atmosphere must be able to remove these, although the diet should be planned to minimize the problem. The collection of urine and its storage is of importance, particularly on short-term flights, and individual packaging and labeling of urine specimens will be necessary for the analyses. Metabolism An accurately measured intake of nutrients, calories, and water is necessary for determining metabolic demands imposed in any space flight. There is insufficient knowledge to predict total metabolic requirements under the numerous stresses which can be anticipated. Simulator studies are of great importance even for short-duration flights. The two most important variables to be considered in establishing the minimal diet are protein and energy requirements. NASA is supporting research at the University of California (Berkeley) to determine these requirements and to estimate individual variation in healthy young men. The possibility of minimizing need through biological adaptation is being explored. It is difficult to estimate the minimum protein requirement of an adult man. The generally accepted criterion of minimum adequate protein nutrition in the adult is the maintenance of nitrogen balance at minimum intake. The minimum protein requirements depend on endogenous nitrogen loss. Analysis of the little data available indicates a best estimate of 2 mg of nitrogen per kilocalorie of basal energy expenditure. However, this figure is higher than that noted in experiments in some human subjects.