The question "Is life limited to this planet?" can be considered on a statistical basis. Although the size of the sample (one planet) is small, the statistical argument for life elsewhere is believed by many to be very strong. While Mars is generally considered the only other likely habitat of life in our solar system, Shapley ([ref.35]) has calculated that more than 100 million stars have planets sufficiently similar in composition and environment to Earth to support life. Of course, yet unknown factors may significantly reduce or even eliminate this probability. SPACECRAFT STERILIZATION The search for extraterrestrial life with unmanned space probes requires the total sterilization of the landing capsule and its contents. Scientists agree that terrestrial organisms released on other planets would interfere with exobiological explorations (refs. [ref.36]-[ref.43]). Any flight that infects a planet with terrestrial life will compromise a scientific opportunity of almost unequaled proportions. Studies on microbiological survival in simulated deep-space conditions (low temperature, high ultraviolet flux, and low dose levels of ionizing radiation) indicate that these conditions will not sterilize contaminated spacecraft (refs. [ref.44]-[ref.48]). Furthermore, many terrestrial sporeformers and some vegetative bacteria, especially those with anaerobic growth capabilities, readily survive in simulated Martian environments (refs. [ref.49]-[ref.54]). It has been estimated that a single micro-organism with a replication time of 30 days could, in 8 years of such replication, equal in number the bacterial population of the Earth. This potential could result not only in competition with any Martian life, but in drastic changes in the geochemical and atmospheric characteristics of the planet. To avoid such a disaster, certainly the first, and probably many succeeding landers on Mars, must be sterile—devoid of terrestrial life ([ref.55]). Since the space environment will not in itself kill all life aboard, the lander must leave the Earth in a sterile condition. The sterility of an object implies the complete absence of life. The presence of life or the lack of sterility may be proven; but the absence of life or sterility cannot be proven, for the one viable organism that negates sterility may remain undetected. Many industrial products which must be guaranteed as sterile cannot be tested for sterility in a nondestructive manner. A similar situation exists in determining the sterility of a spacecraft. Certification of sterility—based on experience with the sterilizing process used, knowledge of the kinetics of the death of micro-organisms, and computation of the probability of a survivor from assays for sterility—is the only accurate approach to defining the sterility of such treated items.