Perhaps we may begin at the utmost limits of the subject by remarking that in matters of natural and physical science we are met at the outset with the scarcely solved question as to our own place in the nature which we study, and the bearing of this on the difficulties we encounter. The organism of man is decidedly a part of nature. We place ourselves, in this aspect, in the sub-kingdom vertebrata and class mammalia, and recognise the fact that man is the terminal link in a chain of being, extending throughout geological time. But the organism is not all that belongs to man, and when we regard him as a scientific inquirer, we raise a new question. If the human mind is a part of nature, then it is subject to natural law, and nature includes mind as well as matter. Indeed, without being absolute idealists we may hold that mind is more potent than matter, and nearer to the real essence of things. Our science is in any case necessarily dualistic, being the product of the reaction of mind on nature, and must be largely subjective and anthropomorphic. Hence, no doubt, arises much of the controversy of science, and much of the unsolved difficulty. We recognise this when we divide science into that which is experimental, or depends on apparatus, and that which is observational and classificatory--distinctions these which relate not so much to the objects of science as to our methods of pursuing them. This view also opens up to us the thought that the domain of science is practically boundless, for who can set limits to the action of mind on the universe, or of the universe on mind. It follows that science, as it exists at any one time, must be limited on all sides by unsolved mysteries; and it will not serve any good purpose to meet these with clever guesses. If we so treat the enigmas of the sphinx nature, we shall surely be devoured. Nor, on the other hand, must we collapse into absolute despair, and resign ourselves to the confession of inevitable ignorance. It becomes us rather boldly to confront the unsolved questions of nature, and to wrestle with their difficulties till we master such as we can, and cheerfully leave those we cannot overcome to be grappled with by our successors.