Fearful that he should not succeed in relieving the Indians in the new settlements, he requested from the Emperor the grant of a district, then unoccupied, from the gulf of Paria to Cape de la Vela, thus including Cumana, Barcelona, Venezuela, Coro, and Maracaybo. In his memorial, he proposed settling this country with a colony of priests, husbandmen, and labourers; he engaged in two years, to instruct the natives in the arts of social life; to civilize 10,000 of them, and that at the end of that time, the king should derive a revenue of 15,000 ducats, which was to increase to 50,000 in ten years. After much difficulty, in consequence of the opposition of the meddling bishop, this extent of coast was granted to him, with liberty to extend it indefinitely into the interior. He sailed from Spain with 200 followers in 1521. Many of these left him at Puerto Rico, others died, and he landed on the coast of Cumana, with a few only who still adhered to him; here he found the country in a state of great agitation from a recent invasion of the Spanish islanders, who had attacked the natives, for the purposes of procuring slaves and gold. He was obliged to go over to Hispaniola to procure a reinforcement, and during his absence, the Indians attacked the colony he had planted, destroyed many of the people, and forced the remnant to take refuge in the little isle of Cubagua. This isle they soon abandoned, and not a Spaniard was then left in any part of the continent from Paria to Darien. Las Casas, mortified beyond every thing, by the failure of his splendid schemes, shut himself up in the Dominican convent at Hispaniola. Here he devoted himself to the performance of religious duties, still keeping in mind the great object of his ambition. The sufferings of the Indians increasing daily, and a chapter of his order at Chiapa in New Spain, having made him their messenger to Europe, on some important affairs, he once more revisited Madrid in 1542, and took a favourable opportunity of pleading the cause of the injured Indians before Charles V. He also composed a treatise, which he called "A Brief Relation of the Destruction of the Indians;" in which was painted, in the most pathetic and forcible manner, the enormities which had taken place in every country of the New World which the Spaniards had visited. This work created the most lively sensations throughout Europe, and such a general abhorrence of the cruel measures of the adventurers, that the Spanish court thought fit to adopt some measures to silence the universal clamour. New regulations were adopted, some of which tended to ameliorate the condition of the unfortunate Americans; and Las Casas was elevated to the dignity of bishop of Chiapa, in order to afford every relief in the power of the church to bestow.