At first the calf retains its appetite, but as the severity of the disease increases the animal shows less and less disposition to suck, and has lost all vivacity, lying dull and listless, and, when raised, walking weakly and unsteadily. Flesh is lost rapidly, the hair stands erect, the skin gets dry and scurfy, the nose is dry and hot, or this condition alternates with a moist and cool one. By this time the mouth and skin, as well as the breath and dung, exhale the peculiar, penetrating, sour, offensive odor, and the poor calf has become an object of disgust to all that approach it. At first, and unless inflammation of the stomach and bowels supervenes (and unless the affection has started in indigestion and colic), the belly is not bloated or painful on pressure, symptoms of acute colicky pains are absent, and the bowels do not rumble; neither are bubbles of gas mingled with the feces. The irritant products of the intestinal fermentations may, however, irritate and excoriate the skin around the anus, which becomes red, raw, and broken out in sores for some distance. Similarly the rectum, exposed by reason of the relaxed condition of the anus, or temporarily in straining to pass the liquid dejection, is of a more or less deep red, and it may be ulcerated. Fever, with rapid pulse and increased breathing and temperature, usually comes on with the very fetid character of the feces and is more pronounced as the bowels become inflamed, the abdomen sore to the touch and tucked up, and the feces more watery and even mixed with blood.