The late Professor Hack, of Freiburg, in 1884, called general medical attention to the intimate connection between the nose and states of nervous hyperexcitability in various parts of the body, although such a connection had been recognized for many centuries in medical literature. While Hack and his disciples thus gave prominence to this association, they undoubtedly greatly exaggerated its importance and significance. (Sir Felix Semon, _British Medical Journal_, November 9, 1901.) Even many workers who have more recently further added to our knowledge have also, as sometimes happens with enthusiasts, unduly strained their own data. Starting from the fact that in women during menstruation examination of the nose reveals a degree of congestion not found during the rest of the month, Fliess (_Die Beziehungen zwischen Nase und Weiblichen Geschlechtsorganen_, 1897), with the help of a number of elaborate and prolonged observations, has reached conclusions which, while they seem to be hazardous at some points, have certainly contributed to build up our knowledge of this obscure subject. Schiff (_Wiener klinische Wochenschrift_, 1900, p. 58, summarized in _British Medical Journal_, February 16, 1901), starting from a skeptical standpoint, has confirmed some of Fliess's results, and in a large number of cases controlled painful menstruation by painting with cocaine the so-called "genital spots" in the nose, all possibility of suggestion being avoided. Ries, of Chicago, has been similarly successful with the method of Fliess (_American Gynæcology_, vol. iii, No. 4, 1903). Benedikt (_Wiener medicinische Wochenschrift_, No. 8, 1901, summarized in _Journal of Medical Science_, October, 1901), while pointing out that the nose is not the only organ in sympathetic relation with the sexual sphere, suggests that the mechanism of the relationship is involved in the larger problem of the harmony in growth and in nutrition of the different parts of the organism. In this way, probably, we may attach considerable significance to the existence of a kind of erectile tissue in the nose.