An interesting example of a reflex influence from the nose affecting the genital sphere has been brought forward by Dr. E.S. Talbot, of Chicago: "A 56-year-old man was operated on (September 1, 1903) for the removal of the left cartilage of the septum of the nose owing to a previous traumatic fracture at the sixteenth year. No pain was experienced until two years ago, when a continual soreness occurred at the apical end of the fracture during the winter months. The operation was decided upon fearing more serious complications. The parts were cocainized. No pain was experienced in the operation except at one point at the lower posterior portion near the floor of the nose. A profound shock to the general system followed. The reflex influence of the pain upon the genital organs caused semen to flow continually for three weeks. Treatment of general motor irritability with camphor monobromate and conium, on consultation with Dr. Kiernan, checked the flow. The discharge produced spinal neurasthenia. The legs and feet felt heavy. Erythromelalgia caused uneasiness. The patient walked with difficulty. The tired feeling in the feet and limbs was quite noticeable four months after the operation, although the pain had, to a great extent diminished." (Chicago Academy of Medicine, January, 1904, and private letter.) J.N. Mackenzie has brought together a great many original observations, together with interesting quotations from old medical literature, in his two papers: "The Pathological Nasal Reflex" (_New York Medical Journal_, August 20, 1887) and "The Physiological and Pathological Relations between the Nose and the Sexual Apparatus of Man" (_Johns Hopkins Hospital Bulletin_, January 1, 1898). A number of cases have also been brought together from the literature by G. Endriss in his Inaugural Dissertation, _Die bisherigen Beobachtungen von Physiologischen und Pathologischen Beziehungen der oberen Luftwege zu den Sexualorganen_, Teil. II, Würzburg, 1892. The intimate association between the sexual centers and the olfactory tract is well illustrated by the fact that this primitive and ancient association tends to come to the surface in insanity. It is recognized by many alienists that insanity of a sexual character is specially liable to be associated with hallucinations of smell.