Studies on Epidemic Influenza: Comprising Clinical and Laboratory InvestigationsUniversity of Pittsburgh. School of Medicine
History
Studies on Epidemic Influenza: Comprising Clinical and Laboratory Investigations
University of Pittsburgh. School of Medicine
Influenza; Influenza Epidemic, 1918-1919
Where the inflammatory œdema was accompanied by much focal hemorrhage
the distribution was nodular and suggested the appearance of the
hemorrhagic lung of plague pneumonia. It was this appearance which led
to the suggestion that the pandemic was not one of influenza but
possibly of an infection related to the eastern plague. The nodular
masses of hemorrhage at times occupied areas varying from the size of a
walnut to that of a golf ball and were localized amidst a relatively
mildly involved lung tissue making a sharp contrast between the involved
and relatively normal tissue. With the removal of the lung from the body
and the partial collapse of the aerated tissues these nodules became
still more prominent. The greater the amount of hemorrhage within these
areas the more solid became the occupied tissue. Such sporadic
distribution of hemorrhagic lesions occurred in the two most intense and
rapidly fatal cases. Both of these individuals died within 48 hours of
the time of onset of the lung conditions. In these two cases we do not
believe that the pulmonary lesions had been prolonged over a time even
as long as 36 hours but with the difficulty of estimating the onset of
the lung involvement we are giving a liberal estimate of this time.
Besides meeting with the stages of congestion, œdema and hemorrhage
during the earliest days of the pulmonary lesions we have found that
they are to be encountered virtually through all the stages of the fatal
cases either as remnants of the original reactions which had not been
entirely obliterated by the succeeding purulent process or as was so
commonly found, new reactions occurred in other regions of the lung so
that, in the same individual, inflammatory reactions of different stages
of development could be defined. I do not recollect a single autopsy of
a case dying during the acute period which did not show evidence of some
areas in the stages of this early acute reaction. Naturally where
resolution is well advanced within the lung all trace of inflammatory
exudate of various kinds is removed and where such individuals with
their resolved pneumonia are brought to death through succeeding
complications the above finding will not be borne out. We limit,
however, our statement to the findings in the acute deaths.
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