Studies on Epidemic Influenza: Comprising Clinical and Laboratory InvestigationsUniversity of Pittsburgh. School of Medicine
History
Studies on Epidemic Influenza: Comprising Clinical and Laboratory Investigations
University of Pittsburgh. School of Medicine
Influenza; Influenza Epidemic, 1918-1919
We have previously intimated that the œdema present in the early stages
of the reaction is to be looked upon as an inflammatory œdema or better
as a true serous exudate, and must not be confused with the transudation
of fluids in non-inflammatory conditions. We have on several occasions
collected the fluid expressed from the soggy lungs and have made some
determinations of their chemical qualities. The difficulty immediately
arises in separating the materials arising from cellular degeneration
from the natural constituents of the serous exudate. We were unable to
obtain specimens in which laked blood was not present, so that even
though the cellular constituents and fibrin were removed, decomposition
products could not be separated. The analyses, however, gave a
differentiation from the transudate seen in renal and cardiac
conditions.
During the period of the accumulation of this inflammatory fluid the
clinician could often recognize a profuse watery exudate within the lung
or even observed an abundant serous discharge arising in bronchi and
trachea. At times the quantity of expectoration was great. Frothy serous
fluid accumulated in the air passages and would periodically be
expectorated. At other times the hemorrhage was of quite serious extent
and the patient would suddenly bring up several mouthfuls or more of
bright blood. This pulmonary hemorrhage was without manifestations
different from the acute illness with cyanosis of other individuals. The
two most acute cases, which we have referred to above, were of this
kind, both of them having marked hæmoptysis with the loss of upwards of
a pint of blood at a time.
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