While I consider a moderate use of wine and beer advantageous-except, of course, where beer, as is often the case, affects the liver, I regard the use of spirits as wholly deleterious, except when medically required, and should like to see the tax upon spirits raised tenfold. A glass of spirits and water may do no harm, but there is such a tendency upon the part of those who use them to increase the dose, and the end is, in that case, destruction to mind and body. G. A. HENTY. February 22, 1882. MR. OLIVER WENDELL HOLMES Prefers an entirely undisturbed and unclouded brain for mental work, unstimulated by anything stronger than tea or coffee, unaffected by tobacco or other drags. His faculties are best under his control in the forenoon, between breakfast and lunch. The only intellectual use he could find in stimulants is the quickened mental action they induce when taken in company. He thinks ideas may reach the brain when slightly stimulated, which remain after the stimulus has ceased to disturb its rhythms. He does not habitually use any drink stronger than water. He has no peremptory rule, having no temptation to indulgence, but approaching near to abstinence as he grows older. He does not believe that any stimulus is of advantage to a healthy student, unless now and then socially, in the intervals of mental labour. MR. GEORGE JACOB HOLYOAKE. I never took enough of stimulants to tell whether it is good or ill for "thinking and working." Tobacco is only good when you have a habit of working too much, as it makes you lazy-minded. G. J. HOLYOAKE. April 3, 1882. SIR J. D. HOOKER, F. R. S. I have had no experience on the subject of the use of tobacco and alcohol that is of any value, or you should be welcome to it. Jos. D. HOOKER. Feb. 13, 1882. MR. W. D. HOWELLS. If you will allow me to count myself out of the list of "great thinkers "and _very_ "popular authors," I will gladly contribute my experience in the points you publish. I never use tobacco, except in a very rare, self-defensive cigarette, where a great many other people are smoking; and I commonly drink water at dinner. When I take wine, I think it weakens my work, and my working force the next morning. W. D. HOWELLS. March 2, 1882. DR. J. P. JOULE. I am afraid that my experience can be of little use to you, because I have lived a very uniform life; and am therefore unable to compare the consequences from following various _regimes_.. I use alcoholic beverages moderately. I do not think they ever assisted or retarded my mental work. As for tobacco, it is the object of my aversion, as it must be to all non-smokers to whom the habits of the consumers of the weed must always appear more or less as an impertinence. Besides, it is difficult to imagine how the use of narcotics can be indulged in with impunity to the health. J. P. JOULE. February 11, 1882. THE REV. HENRY LANSDELL.