In reply to your enquiries, I have to say that my experience of the effects of alcohol and tobacco upon intellectual work is a very limited one, owing to the very moderate use I have made of either. So far, however, as my experience goes, my conclusions are as follows: tobacco, though it may, indeed, give a momentary fillip to the faculties, lessens their power of endurance; for by lowering the action of the heart, it diminishes the blood supply to the brain, leaving it imperfectly nourished, and flaccid, and unable, there-fore, to make due response to the demands of its owner, the man within, who seeks to manifest himself through the organism. Of an organism thus affected, as of an underpitched musical instrument, the tones will be flat. Of stimulants, the effect is the contrary. Owing to the over-tension of the strings, the music will be sharp. It is apt also to be irregular and discordant, owing to the action set up in the organism itself--an action which is not that of the performer or man. That which alone ought to find expression, is the central, informing spirit of the individual; and for both idea and expression to be perfect, the first essential is purity, mental as well as physical. Hence, however great a man and his work may be, under the influence of alcohol or tobacco, or on a diet of flesh, they would be still greater on pure natural regimen. Of course, there are cases in abundance in which persons have become so depraved by evil habits, as to be utterly incapacitated through the disuse of that to which they have been accustomed. But no sound argument in favour of the abuse can be founded on this. EDWARD MAITLAND. March 20, 1882. SIR THEODORE MARTIN, K. C. B. To myself tobacco is simply poison, and I believe it is so to very many who use it. I have seen proofs that it is so among the friends of my youth, who certainly hurt their health and shortened their lives by smoking. But, on the other hand, I have known others who smoked with impunity, and even with benefit to their nervous system. These, however, are, in my experience, exceptional cases. Wine in moderation is, I am sure, beneficial to brain workers; and I feel confident that it is far better, as a rule, to assist the system by this, than by food without wine or alcohol, which, in my experience, seems always to lead to eating to an extent that is very apt to cause derangement of the functions of the body. But, really, I have not made my observations either with such care or on so wide a scale as to give them any value. THEODORE MARTIN. February 18, 1882. THE REV. JAMES MARTINEAU, D. D.