I have no difficulty in making known to you my views on the effects of tobacco and alcohol. I believe both to be extremely injurious, as they are the cause of many diseases, even when taken in small quantities, and much more so when indulged in to excess. I have never used them personally, but I have only too often observed their baneful influence on individuals of my acquaintance. I do not even consider wine to be harmless, especially as it is most usually adulterated. I have abstained from it for many years, indeed for nearly a lifetime, with great advantage. In our climate none of these stimulants are needed, and I very much question whether they are more necessary elsewhere. Accept my thanks for the questions you have addressed to me. B. ST. HlLAIRE. Feb. 24, 1882. MR. W. SPOTTISWOODE, D. C. L., LL. D., PRESIDENT OF THE ROYAL SOCIETY. In reply to your enquiry, I beg to say that I have never smoked, and that I take wine only at meals, and in moderation. I have never observed any noticeable effect from wine so taken on mental work, but should think it quite insignificant. W. SPOTTISWOODE. DR. C. W. SIEMENS, D. C. L., F. R. S. My experience has only extended to a very moderate use of alcohol and tobacco. I find that even the most moderate use of tobacco is decidedly hurtful to energetic mental effort. With regard to alcohol, a very moderate amount does not appear to depress the mental condition, under ordinary circumstances, but I find that although I never indulged in its use I can do very well without it, and I am doing with less and less. Under certain conditions, however, I find that alcohol has a beneficial effect in restoring both mind and body to a state of power and activity. C. W. SIEMENS. Dec. 4th, 1882. MR. G. BARNETT SMITH. I should probably not be accepted as an authority upon the tobacco question, as I have never smoked a pipe or cigar in my life. As to the use of alcohol, the moderate quantity I have taken has not been detrimental to me, and, in consequence of the state of my health, it has sometimes been necessary. No doubt a larger quantity of stimulant than is essential is taken by many literary men, and by other classes of the community; but a moderate quantity would, I believe, be found beneficial by most writers. Of course, if a man finds that he can do quite as well without alcohol, he is undoubtedly wise in discarding it. G. BARNETT SMITH. March 28, 1882. M. TAINE.