In reply to your enquiry, I have to inform you that I have never smoked, and have always drunk wine, chiefly claret. As to the use of wine, I can only speak for myself. Of course, there is the danger of excess; but a healthy nature and the power of self-control being presupposed, one can hardly do better, I should think, than "follow nature" as to what one drinks, and its times and quantity. As a general rule, I drink water in the middle of the day; and a glass or two of sherry, and some light claret, mixed with water, at a late dinner; and this seems to suit me very well. I have given up beer in the middle of the day, not because I experienced that it did not suit me, but because the doctor assured me that it was bad for rheumatism, from which I sometimes suffer. I suppose most young people could do as much without wine as with it. Real brain-work of itself, I think, upsets the worker, and makes him bilious; wine will not cure this, nor will abstaining from wine prevent it. But, in general, wine used in moderation seems to add to the _agreeableness_ of life--for adults, at any rate; and whatever adds to the agreeableness of life adds to its resources and powers. MATTHEW ARNOLD. November 4, 1882. PROFESSOR AYRTON Has no very definite opinions as to the effects of tobacco and alcohol upon the mind and health, but as he is not in the habit of either taking alcohol or of smoking, he cannot regard those habits as essential to mental exertion. April 21, 1882. DR. ALEXANDER BAIN, LORD RECTOR OF ABERDEEN UNIVERSITY.