1.--Whole populations have attained to a high degree of civilization and prosperity without having known either tobacco or alcohol, therefore, these substances are neither necessary nor even useful to individuals as well as races. 2.--Very considerable quantities of these drugs, taken at a single dose, may cause death; smaller quantities stupefy, or kill more slowly. They are, therefore, poisons against which we must be on our guard. 3.--On the other hand, there are innumerable persons who drink alcoholic beverages, and smoke tobacco, without any detriment to their reason or their health. There is, therefore, no reason to forbid the use of these substances, while suitably regulating the quantity to be taken. 4.--The use of alcoholic liquors and of tobacco in feeble doses, affords to many persons very great satisfaction, and is altogether harmless and inoffensive. We ought, therefore, to attach no stigma to their consumption, after having pointed out the danger of their abuse. In short, it is with alcohol and tobacco as with all the pleasures of this life--a question of degree. As for myself, I never smoke, because I am not fond of tobacco: I very seldom drink alcoholic liquors, but I take wine to all my meals because I like it. PAUL BERT. March 1, 1882. PROFESSOR JOHN STUART BLACKIE. My idea is, that work done under the influence of any kind of stimulants is unhealthy work, and tends to no good. I never use any kind of stimulant for intellectual work--only a glass of wine during dinner to sharpen the appetite. As to smoking generally, it is a vile and odious practice; but I do not know that, unless carried to excess, it is in any way unhealthy. Instead of stimulants, literary men should seek for aid in a pleasant variety of occupation, in intervals of perfect rest, in fresh air and exercise, and a cultivation of systematic moderation in all emotions and passions. J. S. BLACKIE. February 9, 1882. M. LOUIS BLANC. In answer to your letter, I beg to tell you that I do not know by experience what may be the effects of tobacco and alcohol upon the mind and health, not having been in the habit of taking tobacco and drinking alcohol. LOUIS BLANC. March 9, 1882. MR. J. E. BOEHM, R. A.