+Diapedesis.+ When the circulation becomes very low and the pressure very high, there is a tendency of the red corpuscles to leave the vessel. This is a purely passive process, and is observed only when the changes in the vessel wall are extreme. Both varieties of these cells die and are destroyed in the exudate, the former furnishing the fibrin which is so abundant in some forms of inflammation. This escape of red corpuscles is known as _diapedesis_, and is sometimes so extensive as to amount to capillary hemorrhage. +Symptoms.+ From antiquity the local symptoms of inflammations have been enumerated, as heat, redness, pain and swelling and to these has been added, impaired function. The _redness_ is due to congestion. The _pain_ is due to the pressure exerted on the sensory nerves by the surrounding swelling, as is well shown by the intensification of the distress, as every beat of the heart forces more blood into the space already filled. In some cases, however, it may be caused by the direct action of the inflammatory agent upon the nerves. The _heat_ is caused by the increased supply of warm arterial blood, for it has been abundantly proven that the temperature never rises above the heat of the blood, although naturally in a patient with fever, it will be above the normal temperature of that fluid. The _swelling_ is due to the dilated vessels, and to the escape of serum and blood cells from the vessels into the tissues. The _impaired function_ is chiefly caused by the pain which is often increased by any attempt to use the part, and by the swelling which prevents free movement, though the loss of function may also be dependent upon the direct action of inflammation upon the nerves. The constitutional symptoms of inflammation are an elevation of temperature with or without a chill. There are also other disturbances, such as nausea, vomiting, diarrhea, sweating and polyuria. These are due to efforts on the part of the general economy to eliminate toxic substances. The inflammatory products may poison the system in two ways: (1) by the diffusion of their chemical substances, (toxins and ptomains), or (2) by the passage of bacteria themselves into the blood. +Termination.+ Inflammation may result in resolution, suppuration, necrosis or sloughing, or in the establishment of a chronic state. +Resolution.+ Resolution is the termination of an inflammation by the gradual cessation of all the changes which have occurred. The pain subsides, the circulation becomes more normal, and the exudate is absorbed, or makes its way to the free surface of the body, where drainage occurs either spontaneously or by incision. If there has been any loss of substance caused by the inflammation, it is restored by processes exactly similar in character to those in the repair of wounds.