In this house Sir Isaac Newton resided for many years; and it was here, according to his biographer, that he dispensed, under the superintendence of his beautiful niece, an elegant hospitality. Our sketch gives a good idea of the appearance of the exterior of the house at the present day; the front, it will be seen, has been well plastered, which, although clean and pleasant-looking to some eyes, seems to us to destroy the character of the building. The old doorway, with a projecting top, has also been removed. The interior of the house is in excellent repair, and has undergone very little change. The cornices, panelling, and the spacious staircase, are not altered since the days of Newton. The rooms are very large. Tradition states it was in the back drawing-room that the manuscript of his work, the "New Theory of Light and Colours," was destroyed by fire, caused by a favourite little dog in Sir Isaac's absence. The name of this canine incendiary was Diamond. The manner in which the accident occurred is thus related:--The animal was wantoning about the philosopher's study, when it knocked down a candle, and set fire to a heap of manuscript calculations upon which he had been employed for years. The loss was irretrievable; but Sir Isaac only exclaimed with simplicity, "Ah, Diamond, Diamond, you little know what mischief you have been doing!" Passing upstairs, and looking slightly at the various rooms, which are all well panelled, but which do not require particular notice, we reached the little observatory shown in the engraving. There, in the room in which Sir Isaac has quietly studied, and in which he may have held conferences with the most distinguished of his contemporaries, we found two shoemakers busily at work, with whom we had some pleasant conversation. Our artist has represented the interior of the observatory, with its laborious occupants, worthy sons of St. Crispin. Shoemakers are well known to be a thoughtful class of men, although sometimes they unfortunately do not make the best use of their knowledge. Brand, the historian and author of the excellent book on "Popular Antiquities," was at one time a shoemaker; so was Bloomfield, the poet, who, when working at the "last" in Bell Alley, near the Bank, strung together the charming recollection of his plough-boy life. We could give a long list of shoemakers who have been eminent for talents. We have not the exact date at which Newton came to reside here, but certainly he was living in this house, at intervals, after 1695, when he was appointed Warder of the Mint, of which establishment he rose to be Master in the course of three years. The emoluments of this office amounted to L1200 a-year, which enabled him to live in ease and dignity. In 1703 he was chosen President of the Royal Society--an honourable post, to which he was annually elected until the time of his death. POISONING THE MONARCH.