The cough, hurried breathing, and paroxysms of dyspnœa become aggravated, the general health suffers largely, and death often ensues in a state of great weakness and emaciation. On _dissection_ of such cases the lesions of various old standing diseases of the heart, lungs, or abdominal organs have been met with at times, and such disorders have doubtless assisted in maintaining and aggravating the asthma. The most constant lesions, however, are emphysema of the lung, and accumulations of fat in the mediastinum. =Treatment.= 1st. =During a paroxysm.= This is confined to the administration of antispasmodics either by inhalation or as an injection to avoid the additional suffering of swallowing. Ether or chloroform may be inhaled from a sponge, but the employment of these should be guarded especially in advanced cases when besides the prevailing weakness there is reason to suspect structural changes in the heart. The same agents in doses of one, two or three teaspoonfuls, or laudanum in double that quantity may be thrown up as an enema, and may be combined with a couple of ounces of castor oil when costiveness exists. The fumes from burning stramonium or from burning brown paper which has been previously soaked in a strong solution of nitrate of potass, will in many cases suddenly cut short the paroxysm. If on the other hand there is reason to believe that the stomach is overloaded the attacks will often be suddenly cut short by giving an emetic. For this purpose a grain of tartar emetic may be shaken upon the tongue, or a dessert spoonful of wine of ipecacuan, or of antimony, poured over the throat. 2d. =In the intervals between the paroxysms.= Attention must be given to counteract any inflammatory action in the chest by which the disease may be maintained. Our chief object, however, must be to divest the animal of its superfluous fat and bring the digestive organs into a healthy condition. Unfortunately the propensity to fatten in some dogs seems to be a morbid condition. The food appears to be stored up as fat at the expense of muscular and other tissues even when the animal is kept on the borders of starvation. All flesh must be withheld and coarse vegetable fare alone allowed. A well boiled pudding (porridge) made with oatmeal or Indian corn meal, water and a little salt, with a small quantity of skimmed milk or buttermilk, is an excellent diet in such cases. The amount must be small, though the hitherto pampered favorite will rarely seek to fully replenish his stomach until he has forgotten his former extravagant habits.